Holders Dundalk, who progressed past St Patrick’s Athletic in a penalty shoot-out in the last round, will host Bohemians in the stand out tie of the round.
Cobh Ramblers await the winners of the 3rd Round tie between Shamrock Rovers and Longford Town, while the winners of the postponed fixture between Munster rivals Waterford and Cork City will face a trip to the Showgrounds to face Sligo Rovers.
The Brandywell will play host to Derry City’s game against the winners of Shelbourne’s tie with Drogheda United.
The EA SPORTS Cup Quarter Final draw in full:
Cobh Ramblers v Shamrock Rovers/Longford Town
Dundalk v Bohemians
Sligo Rovers v Waterford/Cork City
Derry City v Shelbourne/Drogheda United
Fixtures to be played on Monday 7 / Tuesday 8, May 2018